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Skip to main content AACR Publications Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics Register Log in My Cart Advertisement Main menu Home About The Journal AACR Journals Subscriptions Permissions and Reprints Reviewing Articles OnlineFirst Current Issue Past Issues Meeting Abstracts Collections Focus on Computer Resources Highly Cited Collection Editors' Picks For Authors Information for Authors Author Services Early Career Award Best of: Author Profiles Submit Alerts Table of Contents Editors' Picks OnlineFirst Citations Author/Keyword My Alert Summary & Preferences News Cancer Discovery News AACR Publications Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics User menu Register Log in My Cart Search Search for this keyword Advanced search Search for this keyword Advanced Search Home About The Journal AACR Journals Subscriptions Permissions and Reprints Reviewing Articles OnlineFirst Current Issue Past Issues Meeting Abstracts Collections Focus on Computer Resources Highly Cited Collection Editors' Picks For Authors Information for Authors Author Services Early Career Award Best of: Author Profiles Submit Alerts Table of Contents Editors' Picks OnlineFirst Citations Author/Keyword My Alert Summary & Preferences News Cancer Discovery News Follow us on Twitter @CR_AACR! Read the February 15th Issue! Cover from "A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition," by Kitchen and colleagues. Review: The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in Cancer Lindsay G. Cowell A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis Kun Liao, et al. Controversy and Consensus: Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis Mahak Singhal and Hellmut G. Augustin A Versatile ES Cell–Based Melanoma Mouse Modeling Platform Ilah Box, et al. 1 2 3 4 5 From the Current Issue Tumor Biology and Immunology A Runaway PRH/HHEX-Notch3–Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition Philip Kitchen , Ka Ying Lee , Danielle Clark , Nikki Lau , Jomnarong Lertsuwan , Anyaporn Sawasdichai , Jutamaad Satayavivad , Sebastian Oltean , Simon Afford , Kevin Gaston and Padma-Sheela Jayaraman Cancer Res February 15 2020 80 (4) 757-770; DOI:10.1158/0008-5472.CAN-19-0942 The PRH/HHEX transcription factor is an oncogenic driver in cholangiocarcinoma that confers sensitivity to CDK4/6 inhibitors. Resource Report A Versatile ES Cell–Based Melanoma Mouse Modeling Platform Ilah Bok , Olga Vera , Xiaonan Xu , Neel Jasani , Koji Nakamura , Jordan Reff , Arianna Nenci , Jose G. Gonzalez and Florian A. Karreth Cancer Res February 15 2020 80 (4) 912-921; DOI:10.1158/0008-5472.CAN-19-2924 This study presents a high-throughput and versatile ES cell-based mouse modeling platform that can be combined with state-of-the-art genetic tools to address unanswered questions in melanoma in vivo . Metabolism and Chemical Biology A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis Kun Liao , Shuye Deng , Liyan Xu , Wenfeng Pan , Shiyu Yang , Fufu Zheng , Xingui Wu , Hongrong Hu , Zhijun Liu , Junhang Luo , Rui Zhang , Dong-Ming Kuang , Jiajun Dong , Yi Wu , Hui Zhang , Penghui Zhou , Jin-Xin Bei , Yang Xu , Yin Ji , Peng Wang , Huai-Qiang Ju , Rui-Hua Xu and Bo Li Cancer Res February 15 2020 80 (4) 675-688; DOI:10.1158/0008-5472.CAN-19-2060 A novel feedback loop involving EZH2 and suppression of the gluconeogenesis enzyme FBP1 promotes hepatocellular cancer growth. Controversy and Consensus Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis Mahak Singhal and Hellmut G. Augustin Cancer Res February 15 2020 80 (4) 659-662; DOI:10.1158/0008-5472.CAN-19-3351 See the Table of Contents Recent Reviews Review The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in Cancer Lindsay G. Cowell Cancer Res February 15 2020 80 (4) 643-654; DOI:10.1158/0008-5472.CAN-19-1457 -- OnlineFirst Articles Towards Multidrug Adaptive Therapy Jeffrey West , et al. miR-149 Blocks CSF1-Dependent Signaling Ismael Sánchez-González , et al. Dasatinib for AITL Tran B. Nguyen , et al. Awaking memory immune response to fight the cancer. Siri Tähtinen , et al. Load more Advertisement Back to top Home Alerts Feedback Privacy Policy Facebook Twitter LinkedIn YouTube RSS Articles Online First Current Issue Past Issues Meeting Abstracts Info for Authors Subscribers Advertisers Librarians Reviewers About Cancer Research About the Journal Editorial Board Permissions Submit a Manuscript Copyright © 2020 by the American Association for Cancer Research. Cancer Research Online ISSN: 1538-7445 Cancer Research Print ISSN: 0008-5472 Journal of Cancer Research ISSN: 0099-7013 American Journal of Cancer ISSN: 0099-7374 Advertisement...
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